After taking the four-drug combination for two days, I experienced shortness of breath and a strong sensation of blockage in the upper stomach.

Quadruple therapy is commonly used to treat Helicobacter pylori infection and typically includes antibiotics, a proton pump inhibitor, and bismuth. Difficulty breathing and a feeling of blockage in the upper abdomen after taking the medication may indicate adverse drug reactions. Antibiotics may irritate the gastrointestinal tract, causing gastrointestinal dysfunction and discomfort. Some patients may also be allergic to certain components of the medication, leading to respiratory symptoms.

It is recommended to stop taking the quadruple therapy immediately to prevent further worsening of symptoms. For the sensation of blockage in the stomach, prokinetic agents such as domperidone may be taken under a doctor's guidance to alleviate symptoms. Once the doctor confirms that the symptoms are due to an adverse drug reaction, they may adjust the types or dosages of the quadruple therapy medications and develop a new treatment plan. During subsequent treatment, closely monitor your body's response, and promptly inform your doctor if discomfort recurs.

During treatment, maintain a light and easily digestible diet, and avoid spicy, greasy, or irritating foods to reduce the burden on the gastrointestinal system.