
What causes restless legs syndrome?
My colleague was recently diagnosed with restless legs syndrome. Is this because he sits in the office for long periods? He is only 37 years old—what could have caused this?

The main causes of Restless Legs Syndrome (RLS) include the following categories:
1. Genetic factors: RLS is associated with family inheritance, and some patients have a family history.
2. Nutritional deficiencies: Deficiencies in certain trace elements such as iron, folic acid, or vitamin B12 may trigger RLS. A lack of these nutrients can affect the normal functioning of the neuromuscular system.
3. Medication-related factors: Certain medications, such as antipsychotics, diuretics, and antihypertensive drugs, may lead to RLS by affecting dopamine secretion.
4. Disease-related factors: Various diseases may lead to secondary RLS, such as diabetes, Parkinson's disease, chronic kidney failure, polyneuropathy, and rheumatoid arthritis. These conditions may damage the structure and function of the nervous system, thereby triggering RLS.
5. Other factors: Conditions such as pregnancy, low immunity, and soft tissue injuries in the lumbar and sacral regions may also be associated with the development of RLS.
Therefore, during diagnosis and treatment, it is necessary to comprehensively consider the patient's specific circumstances and conduct a thorough evaluation and examination.