How to Treat "Big Three Positive" (Major Triple Positive) Hepatitis B

Feb 18, 2025 Source: Cainiu Health
Disease description:

Tested positive for "big three positives," very worried. I have learned about some treatment methods, but I don't know which one suits me. I want to know specifically how "big three positives" should be treated, what precautions should be taken during treatment, and whether it can be cured?

Doctor's answer (1)
Dr. Gao Jun

Being positive for the "big three" (commonly known as the hepatitis B big three) generally indicates positive results for hepatitis B surface antigen, hepatitis B e antigen, and hepatitis B core antibody. It can usually be treated with general care, medication, and other treatment methods.

Patients should rest in bed and avoid excessive fatigue and strenuous activities, such as running or playing badminton, to prevent interference with recovery. A balanced diet with moderate consumption of fresh vegetables and fruits, such as tomatoes, carrots, and strawberries, may help alleviate symptoms. Alcohol consumption should be avoided. Maintaining a healthy diet, moderate exercise, enhancing physical health, and reducing the burden on the liver are all important.

Antiviral medications such as nucleoside analogs or interferon, including entecavir and tenofovir, can effectively suppress hepatitis B virus replication and reduce viral load. Patients with elevated transaminase levels but no obvious symptoms may take liver-protecting medications as directed by a physician. Patients at risk of cirrhosis should consider long-term antiviral therapy to prevent the development of cirrhosis and liver cancer.

In addition, patients with chronic diseases often experience psychological stress. Providing psychological support and counseling can help improve treatment adherence and quality of life.