What are the side effects of hyaluronic acid injections?

Feb 21, 2025 Source: Cainiu Health
Disease description:

Planning to receive hyaluronic acid injections, I've heard there may be side effects. I would like to know specifically what the possible side effects are. For example, could there be allergic reactions, scarring, or other adverse effects?

Doctor's answer (1)
Dr. Chen Lu

Possible side effects of hyaluronic acid injections may include infection, tissue necrosis, nodules, vascular embolism, and facial asymmetry.

In the field of cosmetic medicine, hyaluronic acid injection is a common non-surgical aesthetic procedure used to fill wrinkles, reshape contours, or enhance facial volume. Improper operation may lead to infection at the injection site; therefore, it is important to choose a reputable medical facility and an experienced physician. If hyaluronic acid causes an adverse reaction with the body, the injected local tissue cells may necrotize and will not regenerate.

In rare cases, hard lumps or a granular sensation may appear at the injection site, which could be due to incomplete absorption of hyaluronic acid or an immune response. Although rare, vascular embolism can occur if improper injection techniques introduce hyaluronic acid into blood vessels, potentially causing severe complications such as skin necrosis or vision damage. Improper dosage or injection placement may also lead to facial asymmetry, affecting aesthetic appearance.

In addition, injury to local nerves during injection may result in corresponding neurological dysfunction, such as facial droop. It is recommended to choose an experienced physician, undergo treatment at a licensed medical facility, and follow post-operative care instructions provided by the doctor.