Precautions for Penicillin Skin Test

Penicillin skin test, also known as penicillin skin allergy test, is a common method used to determine whether a patient is allergic to penicillin antibiotics.

Firstly, a detailed history of allergy to penicillin or other medications should be obtained from the patient. If the patient has a history of penicillin allergy, the skin test should be avoided. The skin test should be performed in a medical setting with emergency medications and equipment available in case of sudden severe allergic reactions.

Prior to the skin test, the patient should stop taking medications that may interfere with the test results, such as antiallergic drugs, antacids, and corticosteroids. Antihypertensive medications such as metoprolol or captopril should also be discontinued at least one day before the skin test.

The penicillin skin test solution should be prepared and used immediately to ensure accurate dosing. Prolonged storage of the test solution may increase the risk of allergic reactions. After the skin test, the patient should be observed for at least 15–20 minutes for signs of allergic reaction, such as erythema or swelling.

Iodine tincture should not be used to disinfect the skin before the skin test. After the test, the injection site should not be rubbed or covered, as this may interfere with the interpretation of results. Patients with a positive skin test should avoid penicillin antibiotics, and this should be clearly documented in their medical records to prevent inadvertent use in the future.