What Causes Sores at the Corners of the Mouth?
Feb 21, 2021
Source: Cainiu Health
Dr. Li Ruizhi
Introduction
What Causes Sores at the Corners of the Mouth?
1. Psychological factors—possibly related to autonomic nervous system dysfunction;
2. Herpes simplex infection—characterized by painful blisters on the tongue, hard palate, gums, buccal mucosa, and lips;
3. Endocrine imbalance—associated with decreased estrogen levels;
4. Deficiency of trace elements—resulting from inadequate intake of nutrients such as vitamin B₂, iron, and zinc.
If a person develops sores on the mouth, it may lead to angular cheilitis (sores at the corners of the mouth) or pain at the mouth corners. So, what causes angular cheilitis? Below is an explanation.
Causes of Angular Cheilitis
1. Psychological Factors
Angular cheilitis commonly occurs during periods of mental stress, significant emotional fluctuations, or poor sleep quality—potentially linked to autonomic nervous system dysfunction, which in turn lowers immune function and predisposes individuals to oral ulcers.
2. Herpes Simplex Virus Infection
Humans are the sole natural host for the herpes simplex virus (HSV). The virus enters the body via the respiratory tract, oral cavity, eyes, genital mucosa, or broken skin. Due to its tendency toward recurrence, HSV infection is clinically classified into primary and recurrent forms. Characteristic manifestations include painful vesicles on the tongue, hard palate, gingiva, buccal mucosa, and lips. These vesicles readily rupture, ulcerate, and become covered with a grayish pseudomembrane; regional lymphadenopathy and tenderness may also occur.
3. Endocrine Imbalance
Some women experience angular cheilitis around menstruation, possibly related to declining estrogen levels. Medication may only provide temporary relief; accompanying symptoms often include dry mouth, irritability, and constipation. Therefore, maintaining psychological balance during menstruation is essential.
4. Deficiency of Trace Elements
Angular cheilitis is actually a form of angular stomatitis. It is frequently associated with deficiencies in nutrients such as vitamin B₂, iron, and zinc—leading to compromised immunity and recurrent oral corner lesions. Importantly, avoid scratching or picking at the sores; doing so increases the risk of secondary infection and recurrence.
The above outlines the common causes of angular cheilitis. We hope this information is helpful to you.
