What is the normal quantitative level of hepatitis B surface antigen?

Sep 02, 2025 Source: Cainiu Health
Dr. Gao Jun
Introduction
Under normal circumstances, the quantitative determination of hepatitis B surface antigen (HBsAg) has a clearly defined normal range. The reference value for most tests is less than 0.05 IU/mL. Values below this level are generally considered normal, while higher levels require further evaluation based on specific clinical situations. In daily life, it is recommended to undergo regular hepatitis B-related examinations, especially for individuals with a family history of hepatitis B or a history of high-risk exposure.

Generally, the quantitative determination of hepatitis B surface antigen (HBsAg) has a clear normal reference range. Most testing laboratories use a reference value of less than 0.05 IU/mL. Values below this level are usually considered normal, while levels above require further attention depending on the specific clinical context. Detailed analysis is as follows:

In current clinical testing methods, the normal reference standard for quantitative HBsAg is mostly set at less than 0.05 IU/mL. If the test result falls within this range, it indicates that HBsAg is undetectable in the body, usually suggesting no hepatitis B virus (HBV) infection, or that a previous infection has been cleared by the immune system. In such cases, the liver is not in an HBV-infected state and no specific intervention is required for this parameter. If the test result is greater than or equal to 0.05 IU/mL, it may indicate infection with hepatitis B virus. Higher values generally suggest higher viral replication activity in the body.

In daily life, it is recommended to undergo regular hepatitis B-related examinations, especially for individuals with a family history of hepatitis B or those with a history of high-risk exposure, who should regularly monitor changes in these indicators. Additionally, maintaining a regular作息 (sleep-wake cycle), avoiding excessive fatigue, limiting alcohol consumption, and reducing the burden on the liver are all important for maintaining good liver health.

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