How long does it take for hepatitis B to turn negative, and are there still symptoms?

Chronic hepatitis B is a common acute viral hepatitis, primarily caused by the hepatitis B virus (HBV), which can be transmitted through blood or bodily fluids. There are two patterns of disease progression following HBV infection: one is a short-term course, in which the infection may spontaneously resolve within 2 to 3 months after infection; the other is a persistent course, where the virus remains in the body for a long period—possibly several years—requiring antiviral treatment, with potential for permanent seroclearance. Generally, the time for hepatitis B to become negative is around 120 to 150 days. Typically, after 120 days of medication, if test results for HBsAg (hepatitis B surface antigen), HBeAg (hepatitis B e-antigen), and HBV-DNA are all negative, it indicates that the viral infection has been controlled and turned negative. However, during the process of becoming hepatitis B negative, due to a significant reduction in viral load, patients may experience symptoms such as fever, fatigue, abdominal pain, and tiredness, with symptom severity varying among individuals. Therefore, during the phase of turning negative, patients with hepatitis B should actively cooperate with their doctors' treatments and promptly improve their diet and overall physical condition to enhance health and facilitate a quicker recovery.