What does it mean when all three liver enzymes—alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT)—are elevated?
Feb 25, 2023
Source: Cainiu Health
Dr. Jiang Weimin
Introduction
Elevated levels of all three liver enzymes—alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutamine—typically indicate liver function impairment, such as viral hepatitis, alcoholic hepatitis, or cirrhosis. It may also suggest the body is in an abnormal condition. Additionally, autoimmune liver diseases or hepatitis C can lead to elevated levels of these three enzymes. Patients should promptly visit a hospital for testing, including hepatitis C antibody and autoimmune antibody screenings.
Elevated levels of all three liver enzymes—alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutamate dehydrogenase (GLDH)—typically indicate liver damage, such as in viral hepatitis, alcoholic hepatitis, or cirrhosis.
1. Viral Hepatitis
Elevated ALT, AST, and GLDH may result from various types of liver injury or abnormal bodily conditions. When liver function is impaired—for example, due to viral hepatitis—it can lead to increased levels of all three enzymes.
2. Alcoholic Hepatitis
Alcoholic hepatitis can cause elevated ALT, AST, and glutamic acid levels. Excessive alcohol consumption allows alcohol to accumulate in the liver, leading to hepatocyte damage and consequently increased levels of these three enzymes. Drug-induced hepatitis and other conditions may also suggest an abnormal physiological state. The exact diagnosis should be determined based on the patient’s specific symptoms and test results.
3. Cirrhosis
Chronic sleep deprivation and poor rest can lead to abnormal liver function, primarily because the liver requires rest during sleep. If one frequently stays up late and does not get adequate rest, toxins cannot be effectively eliminated, potentially resulting in cirrhosis and elevated levels of ALT, AST, and GLDH. It is important to reduce late-night activities and seek timely medical evaluation.
In addition, autoimmune liver diseases, hepatitis C, and other causes may also lead to elevated levels of these three enzymes. Patients should promptly visit a hospital for tests including hepatitis C antibody and autoimmune antibody screening to identify the underlying cause and receive appropriate treatment.
