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Seven-item tumor marker test for lung tumors

Feb 27, 2023 Source: Cainiu Health
Dr. Guo Xiheng
Introduction
The seven common tumor markers for lung cancer typically include carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC), alpha-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 12-5 (CA12-5), carbohydrate antigen 15-3 (CA15-3), and neuron-specific enolase (NSE). Additionally, if elevated tumor markers are detected, further corresponding imaging studies or endoscopic examinations such as gastroscopy and colonoscopy may be required.

The seven common tumor markers for lung tumors typically include carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC), alpha-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 12-5 (CA12-5), carbohydrate antigen 15-3 (CA15-3), and neuron-specific enolase (NSE).

1. Carcinoembryonic antigen (CEA): This is an indicator reflecting disease status. A significantly elevated CEA level at diagnosis usually requires surgical treatment to reduce its value. As a broad-spectrum tumor marker, CEA has important clinical value in differential diagnosis of malignant tumors, disease monitoring, and evaluation of therapeutic efficacy.

2. Squamous cell carcinoma antigen (SCC): This serves as both an auxiliary diagnostic and prognostic monitoring marker. Its concentration increases with disease progression and decreases when treatment is effective. A subsequent rise during follow-up testing often suggests tumor recurrence or metastasis.

3. Alpha-fetoprotein (AFP): This test is closely related to the development of various tumors and may show elevated levels in multiple tumor types, serving as a positive detection marker for several cancers.

4. Carbohydrate antigen 19-9 (CA19-9): This is a type of auxiliary diagnostic and prognostic monitoring test. Higher values generally correlate with more advanced disease. When levels gradually return to normal, it indicates effective disease control.

5. Carbohydrate antigen 12-5 (CA12-5): Elevated levels suggest a higher probability of malignant tumors. Follow-up retesting is usually required. If tumor marker levels decrease, the initial elevation may be attributed to transient benign conditions. However, persistent or progressively increasing levels, especially if doubling, necessitate further investigation.

6. Carbohydrate antigen 15-3 (CA15-3): This marker helps detect the presence of malignant tumors through blood testing. Retesting is typically needed, and if levels continue to rise, additional examinations are warranted to enable early detection, early diagnosis, and early treatment.

7. Neuron-specific enolase (NSE): This marker is used for screening pulmonary malignant tumors. After confirmation of diagnosis, changes in NSE levels can help monitor treatment response.

In addition, if elevated tumor markers are detected, corresponding imaging studies or endoscopic examinations such as gastroscopy or colonoscopy may also be required.



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