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Which blood test indicators are needed for cervical cancer screening?

Mar 28, 2023 Source: Cainiu Health
Dr. Zhao Xiaodong
Introduction
Cervical cancer is a relatively common malignant gynecological tumor. Blood tests for cervical cancer generally include indicators such as carbohydrate antigen CA125, squamous cell carcinoma antigen, carcinoembryonic antigen (CEA), cytokeratin fragment 211, and alpha-fetoprotein. However, blood tests alone are only for reference; to confirm diagnosis, further examinations such as colposcopy and cervical smear are required. It is recommended to seek timely medical evaluation at a hospital.

Cervical cancer is a relatively common gynecological malignant tumor. Blood tests for cervical cancer generally include tumor markers such as carbohydrate antigen CA125, squamous cell carcinoma antigen (SCC), carcinoembryonic antigen (CEA), cytokeratin fragment 21-1 (CYFRA21-1), and alpha-fetoprotein (AFP). The details are as follows:

1. Carbohydrate Antigen CA125

The normal value of carbohydrate antigen CA125 should be less than 35 kU/L. If blood tests show CA125 levels exceeding 35 kU/L, it may indicate conditions such as cervical cancer, endometrial cancer, pancreatic cancer, or other diseases.

2. Squamous Cell Carcinoma Antigen (SCC)

Under normal circumstances, the squamous cell carcinoma antigen level should be less than 1.5 μg/L. A blood test result higher than 1.5 μg/L may suggest the presence of cervical cancer, esophageal cancer, or similar malignancies.

3. Carcinoembryonic Antigen (CEA)

Normally, the CEA level should be below 5.0 ng/mL. Elevated levels may indicate possible cancers such as pancreatic cancer or cervical cancer.

4. Cytokeratin Fragment 21-1 (CYFRA21-1)

Cytokeratin fragment 21-1 is a component of cytokeratin and is a commonly tested serum tumor marker, with a normal reference range below 3.5 ng/mL. Elevated levels are often associated with organ malignancy or cancerous changes and can aid in the diagnosis of cervical cancer.

5. Alpha-Fetoprotein (AFP)

Alpha-fetoprotein is a glycoprotein that serves as a positive indicator for various tumors, with a normal reference value typically below 25 μg/L. Increased serum AFP levels may indicate the presence of malignant tumors and can also assist in diagnosing cervical cancer.

Blood tests for cervical cancer serve only as a reference. For definitive diagnosis, additional examinations such as colposcopy and cervical smear tests are required. It is recommended to seek timely medical evaluation and cooperate with healthcare providers to complete relevant diagnostic procedures.


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