What does low cholinesterase mean?
Apr 23, 2023
Source: Cainiu Health
Dr. Jiang Weimin
Introduction
Cholinesterase is an important enzyme primarily responsible for breaking down the neurotransmitter acetylcholine. Low levels of cholinesterase can impair the decomposition and metabolism of neurotransmitters to some extent, thereby affecting normal physiological functions of the body. Cholinesterase deficiency is usually caused by factors such as hepatitis, infections, or medications. If symptoms of low cholinesterase occur, it is recommended to seek medical attention and receive appropriate treatment based on the underlying cause.
Cholinesterase is an important enzyme primarily responsible for breaking down the neurotransmitter acetylcholine. Low levels of cholinesterase can impair the decomposition and metabolism of neurotransmitters to some extent, thereby affecting normal physiological functions in the human body. Cholinesterase deficiency is generally caused by factors such as hepatitis, infections, and medications. The details are as follows:
1. Hepatitis
Hepatitis refers to liver disease caused by viruses or other factors. In patients with hepatitis, impaired liver function affects the synthesis and breakdown of cholinesterase. Cholinesterase synthesized in the liver is mainly excreted via bile; when liver function is compromised, the synthesis of cholinesterase is affected, leading to reduced cholinesterase levels. Additionally, during treatment for liver inflammation, some hepatitis patients may take prohibited drugs such as amitriptyline, which can inhibit cholinesterase activity and reduce its function.
2. Infections
Infection is a pathological process. When the body is infected with certain pathogens such as bacteria, viruses, or fungi, it can lead to metabolic disturbances that affect cholinesterase levels. Pathogens can reduce cholinesterase activity through their impact on the neuromuscular system. Furthermore, the body's immune response during infection may produce excessive cytokines and inflammatory mediators, contributing to decreased cholinesterase levels.
3. Medications
Atropine, commonly used in treating gastrointestinal disorders, aids digestion and absorption. However, its side effects must be noted, as atropine can inhibit cholinesterase activity, resulting in lower cholinesterase levels. In addition, certain pesticides and insecticides can also reduce cholinesterase activity within the human body.
Low cholinesterase is a common physiological issue. Besides factors such as hepatitis, infections, and medications, maintaining a healthy diet and lifestyle is also crucial in preventing low cholinesterase levels. If symptoms of low cholinesterase occur, medical consultation is recommended, followed by appropriate treatment based on the underlying cause.
