Is hepatitis B DNA less than 100 IU/mL considered negative?

May 14, 2023 Source: Cainiu Health

Dr. Jiang Weimin

Introduction

Hepatitis B DNA usually refers to the level of hepatitis B virus (HBV) DNA. A level below 100 IU/mL is generally considered low-level viral replication, but it does not equate to seroclearance. Seroclearance means the disappearance of hepatitis B surface antigen (HBsAg), i.e., it is no longer detectable. Only when HBsAg disappears and hepatitis B surface antibody (anti-HBs) appears can seroclearance be confirmed.

Hepatitis B DNA usually refers to the level of hepatitis B virus (HBV) DNA, with a normal value typically considered to be 1.0×10⁴ IU/mL. When the level is below 100 IU/mL, it is generally regarded as indicating low-level viral replication, but this does not equate to seroclearance. The specific analysis is as follows:

Seroclearance means the disappearance of hepatitis B surface antigen (HBsAg), i.e., it is no longer detectable. Only when HBsAg disappears and hepatitis B surface antibody (anti-HBs) appears can seroclearance be confirmed. This process is dynamic and may take a long time to achieve. In some cases, HBV DNA levels may fall below 100 IU/mL while HBsAg remains positive, indicating that viral infection still persists. Even with low viral replication activity, ongoing monitoring and appropriate treatment are still necessary.

Patients are advised to closely monitor their health status. If any discomfort occurs, they should seek medical attention promptly to avoid delaying disease management.

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