Is a low glomerular filtration rate serious?

May 16, 2023 Source: Cainiu Health

Dr. Zhao Xinju

Introduction

Whether a low glomerular filtration rate (GFR) is serious depends on the underlying cause and symptoms; due to individual differences, it cannot be generalized. If the reduced GFR is caused by increased arterial resistance due to hypertension, the condition can usually be effectively reversed and is generally not severe. However, if it results from malignant tumor lesions, the situation is considered more serious.

Whether a low glomerular filtration rate (GFR) is serious depends on the underlying condition. If the disease can be alleviated with medication, it is generally not considered severe. However, if the condition is difficult to control, it may be more serious. The specific analysis is as follows:

1. Not severe

The normal GFR value is typically around (125 ± 15) mL/min in males and about 10% lower in females. A reduced GFR indicates impaired kidney function. If the decreased filtration rate results from increased arterial resistance due to hypertension, the condition can usually be managed under medical guidance using antihypertensive medications such as metoprolol tartrate tablets or furosemide tablets. In such cases, the condition generally improves effectively and is usually not serious.

2. Severe

If a low GFR is caused by malignant tumor progression, the situation is more serious. Cancer cells can spread and damage surrounding tissues or organs. Without proper treatment, this may threaten the patient's survival and negatively impact daily quality of life.

Individuals experiencing edema or those taking diuretics are advised not to undergo GFR testing, as these factors may affect test accuracy. If abnormal values are detected, patients should promptly consult a doctor for diagnosis and treatment.

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Glomerular filtration mechanism

Glomerular filtration is the process of converting systemic blood supply into filtrate, which ultimately becomes urine. This complex regulatory process aims to maintain homeostasis of body fluids, water and electrolytes, and other physiological functions. The glomerulus is the primary filtering unit of the kidney. Blood and filtrate flow through the glomerulus, with blood entering via the afferent arteriole.

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Is a glomerular filtration rate of 63 ml/min requiring treatment?

In general, a glomerular filtration rate (GFR) of 63 ml/min may or may not require treatment, depending on the individual clinical situation. The normal GFR range is typically 80–120 ml/min; a patient's GFR of 63 ml/min falls below this normal range, indicating that there may be structural and functional impairment in the kidneys.