What can be used to treat organophosphate poisoning?
Nov 22, 2022
Source: Cainiu Health
Dr. Yang Shuwen
Introduction
Organophosphate poisoning can be treated by removing the patient from the exposure site, using compound formulations, cholinesterase reactivators, and other methods. In case of organophosphate poisoning, immediately leave the contaminated area; gastric lavage may be performed orally under medical guidance. Treatment involves removing phosphate groups from the esterification site of cholinesterase. Additional therapeutic approaches include cholinergic receptor blockers and hemoperfusion dialysis.
Organophosphorus poisoning can be treated by removing the patient from the exposure site, using compound formulations, and cholinesterase reactivators.
1. Removal from the scene
If organophosphorus poisoning occurs, immediately remove the individual from the contaminated environment and eliminate any remaining organophosphorus substances from the body. Thoroughly wash hair, skin, and other exposed areas. Under medical guidance, gastric lavage may be performed using oral magnesium sulfate, mannitol enema, hydrogen administration, or other methods.
2. Compound formulations
After organophosphorus poisoning, prompt medical attention is required. Under a doctor's supervision, antidotes such as pralidoxime injection, chlorpramidine injection, and atropine tablets should be administered.
3. Cholinesterase reactivators
These agents work by removing phosphate groups from the esterification site of cholinesterase, thereby restoring some enzymatic activity. Under medical supervision, medications such as chlorpramidine tablets, iodopralidoxime injection, and fructose diphosphate may be administered orally or intravenously.
In addition, treatment may include cholinergic receptor blockers or hemoperfusion dialysis. After hemoperfusion dialysis, closely monitor the patient’s condition and watch for potential complications.
