Is a TSH (thyroid-stimulating hormone) level of 4.47 µIU/mL severe?

Generally, the normal range is 0.4–4.0 µIU/mL; a level of 4.47 µIU/mL is considered abnormal and usually indicates hypothyroidism or other conditions such as a TSH-secreting pituitary tumor or thyroid hormone resistance syndrome, which can be serious. The detailed analysis is as follows:

A TSH (thyroid-stimulating hormone) level of 4.47 refers to a patient's serum TSH concentration reaching 4.47 µIU/mL or higher when blood samples are tested. Generally, the normal reference range is 0.4–4.0 µIU/mL, so a value of 4.47 µIU/mL is outside this range and considered elevated. High TSH levels are typically caused by hypothyroidism. Hypothyroidism occurs when thyroid cells are reduced in number or impaired, leading to insufficient production of thyroid hormones and consequently low levels of circulating thyroid hormones. This condition may result from Hashimoto’s disease (chronic thyroiditis), surgical removal of the thyroid gland, or certain medications such as lithium or excessive use of antithyroid drugs. Symptoms associated with elevated TSH may include obesity, weakness, fatigue, insomnia, poor nutritional status, impaired cognition and memory, dry skin, and low blood pressure.

In summary, a TSH level of 4.47 µIU/mL is relatively high and may indicate hypothyroidism or other disorders such as a TSH-secreting tumor or thyroid hormone resistance syndrome. Therefore, if test results are abnormal, it is recommended to cooperate closely with a physician for further evaluation and, based on the underlying cause, receive appropriate treatment.