Is a thyroid-stimulating hormone (TSH) level of 4.47 µIU/mL severe?

Generally, the normal range is 0.4–4.0 µIU/mL; a level of 4.47 µIU/mL is considered abnormal and usually suggests hypothyroidism or other conditions such as a TSH-secreting pituitary tumor or thyroid hormone resistance syndrome, which are serious conditions. The specific analysis is as follows:

A TSH (thyroid-stimulating hormone) level of 4.47 means that during blood testing, the patient's serum TSH concentration reaches 4.47 µIU/mL or higher. Normally, the reference range is 0.4–4.0 µIU/mL, so a value of 4.47 µIU/mL falls outside this range and is considered elevated. High TSH levels are typically caused by hypothyroidism. Hypothyroidism occurs when thyroid cells are reduced in number or impaired, leading to insufficient production of thyroid hormones and consequently low circulating thyroid hormone levels. This condition may result from Hashimoto’s disease (chronic thyroiditis), surgical removal of the thyroid gland, or certain medications such as lithium or excessive use of antithyroid drugs. Symptoms associated with elevated TSH levels may include obesity, weakness, fatigue, insomnia, poor nutritional status, reduced cognitive function and memory, dry skin, and low blood pressure.

In summary, a TSH level of 4.47 µIU/mL is high and may indicate hypothyroidism or other disorders such as a TSH-secreting tumor or thyroid hormone resistance syndrome. Therefore, if test results are abnormal, it is recommended to cooperate closely with a physician for further evaluation and, based on the underlying cause, receive appropriate treatment.