If HPV is negative, is it still necessary to test for E6 and E7?

Jun 01, 2023 Source: Cainiu Health

Dr. Lv Aiming

Introduction

HPV-negative individuals generally do not need to be tested for E6/E7. Specifically, an HPV-negative result usually indicates the absence of human papillomavirus infection. Since E6 and E7 are oncogenes, testing for them is typically unnecessary when HPV is negative. Moreover, E6 and E7 are the primary pathogenic factors responsible for cervical cancer.

Generally, E6/E7 testing is not necessary for individuals who are HPV-negative. The specific analysis is as follows:

An HPV-negative result usually indicates that there is no current human papillomavirus (HPV) infection in the body. Since E6 and E7 are oncogenes associated with cancer development, testing for E6/E7 is generally not required when HPV test results are negative. However, E6 and E7 are key pathogenic factors in cervical cancer. Therefore, for patients diagnosed with cervical cancer, E6/E7 presence can be detected through tissue biopsy to examine whether these genes exist in cervical cells. For individuals who are HPV-negative and have not received the HPV vaccine, it is recommended to visit a qualified medical institution and receive the HPV vaccine based on individual circumstances, thereby preventing cervical cancer caused by HPV infection. Additionally, protective measures should be taken during sexual activity, and any unusual symptoms should prompt immediate medical consultation.

It is advisable to undergo regular full-body health checkups. If any infections are detected, timely treatment should be initiated to prevent disease progression and ensure effective recovery.

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What does it mean to be HPV negative but have inflammation?

HPV negative with inflammation indicates no detection of human papillomavirus infection, but the presence of inflammation. The examination reveals inflammation within the vagina, which results from infections caused by various pathogens. For example, when vaginal flora is imbalanced and lactobacilli decrease, bacterial infections may occur, leading to bacterial vaginitis. Invasion by Candida species can cause candidal infection, resulting in vulvovaginal candidiasis.

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Why is p16 positive when HPV is negative?

In general, P16 positivity indicates an HPV16 (human papillomavirus type 16) infection, which is closely associated with cervical cancer. A negative HPV test but positive P16 result may be caused by factors such as low immunity, repeated invasive procedures, unhealthy behaviors, inflammatory infections, or abnormal cell proliferation. Patients are advised to seek timely medical evaluation and treatment.