What does a high hepatitis B surface antibody level of 200 mIU/mL mean?

Jun 05, 2023 Source: Cainiu Health

Dr. Jiang Weimin

Introduction

A high level of hepatitis B surface antibody at 200 mIU/mL generally indicates that protective antibodies have been successfully produced in the body. Specifically, the hepatitis B surface antibody is an immune response to the hepatitis B virus surface antigen, typically generated either after receiving the hepatitis B vaccine or following a hepatitis B infection. This antibody can neutralize HBsAg in the body.

A high level of hepatitis B surface antibody (HBsAb) at over 200 mIU/mL indicates that the body has already produced corresponding protective antibodies. The specific analysis is as follows:

The hepatitis B surface antibody is part of the immune response to the hepatitis B virus surface antigen, typically produced after receiving the hepatitis B vaccine or following infection with the hepatitis B virus. This antibody can neutralize HBsAg in the body, thereby preventing further infection and replication of the hepatitis B virus. When a person receives the hepatitis B vaccine, the surface antigen in the vaccine stimulates the body to produce an antibody response—namely, the hepatitis B surface antibody. If the level of hepatitis B surface antibody is over 200 mIU/mL after vaccination, it indicates that the vaccine has successfully induced effective protective antibodies. If an individual has never been vaccinated against hepatitis B but still shows a hepatitis B surface antibody level above 200 mIU/mL, this suggests a past infection with the hepatitis B virus that has since been cleared, resulting in the production of protective antibodies.

Whether the antibodies were produced through vaccination or as a result of a previous infection, they both provide protective immunity; therefore, there is no need for excessive concern.

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