What is the normal range for Phe/Tyr?
Aug 25, 2023
Source: Cainiu Health
Dr. Yang Shuwen
Introduction
Phe/Tyr is the ratio of phenylalanine to tyrosine, commonly used in newborn screening to help detect phenylketonuria (PKU) at an early stage. PKU is an inherited metabolic disorder in which patients lack the enzyme phenylalanine hydroxylase, leading to impaired metabolism of phenylalanine and its subsequent accumulation in the body.
Under normal circumstances, the normal range for Phe/Tyr is between 2.5 mg/dL and 5 mg/dL. A detailed explanation is as follows:
Phe/Tyr refers to the ratio of phenylalanine to tyrosine, two amino acids, and is commonly used in newborn screening to help detect phenylketonuria (PKU) at an early stage. PKU is an inherited metabolic disorder in which patients lack the enzyme phenylalanine hydroxylase, leading to impaired metabolism of phenylalanine and its subsequent accumulation in the body. If not detected and treated early, this condition may result in brain damage and intellectual disability. The determination of the normal Phe/Tyr range is typically based on extensive population data and reference values from healthy individuals, generally falling between 2.5 mg/dL and 5 mg/dL. However, Phe/Tyr levels in children and adults may differ, so reference ranges can vary depending on age group.
If you wish to learn more about the specific normal range for Phe/Tyr, it is recommended to consult a healthcare provider or qualified medical professional for expert advice.
