Why does fibrosis still occur despite ongoing antiviral treatment?
Sep 12, 2023
Source: Cainiu Health
Dr. Guo Xiheng
Introduction
In general, persistent antiviral treatment with ongoing fibrosis may be related to factors such as drug side effects, inflammation, disease progression, non-alcoholic fatty liver disease, and chronic viral infections. In addition, it could also be associated with low-level residual HBV. If patients experience any discomfort or symptoms, they should seek timely medical evaluation at a hospital to avoid delaying proper diagnosis and treatment.
In general, ongoing antiviral therapy along with liver fibrosis may be related to factors such as drug side effects, inflammation, disease progression, non-alcoholic fatty liver disease (NAFLD), and chronic viral infections. The specific analysis is as follows:
1. Drug Side Effects
Certain antiviral medications may have hepatotoxic effects. Prolonged use or high doses of these drugs can damage the liver, potentially leading to fibrosis—characterized by excessive accumulation of fibrous tissue in the liver. It is important to follow medical advice, regularly adjust treatment plans, and switch medications as needed.
2. Inflammation
Even with continuous antiviral treatment, if bacterial infection causes hepatic inflammation, localized fibrosis may develop. In severe cases, medications such as adefovir dipivoxil tablets or metronidazole tablets may be used under a doctor's guidance.
3. Disease Progression
Fibrosis represents the process by which chronic liver disease progresses toward cirrhosis. If proper care is not maintained during treatment and the condition worsens, fibrosis may become more severe. Medications such as oseltamivir phosphate capsules or ribavirin tablets may be used according to medical instructions.
4. Non-Alcoholic Fatty Liver Disease (NAFLD)
Non-alcoholic fatty liver disease can disrupt normal liver metabolism, potentially leading to liver fibrosis. Treatment may include liver-protective medications such as Hugan tablets or bicyclol tablets, as prescribed by a physician.
5. Chronic Viral Infections
Certain viral infections, such as hepatitis B and hepatitis C, can trigger long-term chronic inflammatory responses. Persistent inflammation may result in liver tissue fibrosis. Patients may take medications such as Fuzheng Huayu capsules or Compound Biejia Ruangan tablets under medical supervision.
Besides the above, low-level residual HBV infection may also contribute. If patients experience any discomfort or symptoms, they should seek timely medical evaluation at a hospital to avoid delays in diagnosis and treatment.
