Is ivabradine a beta-blocker?
Nov 12, 2023
Source: Cainiu Health
Dr. Wang Xin
Introduction
Under normal circumstances, ivabradine is not a beta-blocker, but rather a selective and specific inhibitor of the sinoatrial node's If current. Typically, beta-blockers primarily reduce heart rate by blocking adrenergic receptors and exerting negative dromotropic effects, whereas ivabradine mainly lowers heart rate through selective and specific inhibition of the cardiac pacemaker If current.
Under normal circumstances, ivabradine is not a beta-blocker, but rather a selective inhibitor of the sinoatrial node If current. The detailed analysis is as follows:
Beta-blockers typically reduce heart rate by blocking adrenergic receptors and exerting negative chronotropic effects. In contrast, ivabradine is a selective and specific inhibitor of the sinoatrial node If current, primarily lowering heart rate by selectively and specifically inhibiting the cardiac pacemaker If current. Therefore, ivabradine is not classified as a beta-blocker.
Long-term use of ivabradine can effectively improve left ventricular function and structure, thereby enhancing the quality of life in patients with heart failure. Additionally, ivabradine has no effect on myocardial excitation-contraction coupling or intracardiac conduction. Moreover, because ivabradine can substitute for beta-blockers, it can be used in patients who have contraindications to beta-blockers, thus avoiding the side effects associated with beta-blocker therapy.
If patients experience any discomfort or symptoms, they are advised to seek timely medical attention at a hospital to prevent delays in diagnosis and treatment.
