How much does the surface antigen need to decrease with interferon treatment to become negative?
Mar 18, 2024
Source: Cainiu Health
Dr. Yang Ziqi
Introduction
The surface antigen usually refers to hepatitis B virus surface antigen. Generally, when the level of hepatitis B virus surface antigen is below 1500 IU/mL, interferon treatment tends to be more effective and has a higher probability of achieving seroclearance. Specific recommendations are as follows: in daily life, one should ensure adequate rest, maintain sufficient sleep, avoid staying up late, and may appropriately participate in outdoor physical activities.
Surface antigen usually refers to hepatitis B virus surface antigen (HBsAg). Generally, when the level of hepatitis B virus surface antigen is below 1500 IU/mL, interferon treatment tends to be more effective and the probability of seroclearance (turning negative) is higher. The detailed analysis is as follows:
Hepatitis B virus surface antigen reflects the presence of hepatitis B virus in the body. When hepatitis B virus levels rise and abnormal liver function occurs—especially significantly elevated alanine aminotransferase (ALT)—this indicates inflammatory activity or fibrosis, consistent with chronic hepatitis, which requires interferon therapy. Lower levels of hepatitis B virus surface antigen suggest a smaller amount of hepatitis B virus in the body. In such cases, interferon treatment can more easily eliminate the virus and achieve HBsAg seroclearance. Typically, when HBsAg is below 1500 IU/mL, interferon treatment yields better outcomes.
In daily life, patients should ensure adequate rest, maintain sufficient sleep, avoid staying up late, and engage in appropriate outdoor activities such as walking or calisthenics, which may help promote recovery.
