Can different types of COVID-19 booster vaccines be mixed?

Oct 30, 2024 Source: Cainiu Health
Dr. Yang Ziqi
Introduction
Currently, the main types of COVID-19 vaccines available in China include inactivated vaccines, adenovirus vector vaccines, and recombinant protein vaccines. Generally, receiving a booster dose using a vaccine based on the same technology platform as the primary series provides better efficacy and greater safety assurance. To ensure the safety and effectiveness of vaccination, it is recommended to prioritize using a booster vaccine that employs the same technological approach as the initial primary immunization.

Generally, it is not recommended to mix different types of COVID-19 booster vaccines. If any adverse symptoms occur, individuals should seek medical treatment at a正规 hospital promptly. The detailed explanation is as follows:

Currently, the main types of COVID-17 vaccines available in China include inactivated vaccines, adenovirus vector vaccines, and recombinant protein vaccines. Generally, using vaccines from the same technological platform for booster doses provides better efficacy and greater safety assurance. For example, if the first two doses received were inactivated vaccines, an inactivated vaccine should also be prioritized for the booster dose. However, under certain special circumstances—such as insufficient vaccine supply or urgent situations where the same type of vaccine is unavailable—a mix of vaccines with different technological platforms may be considered after evaluation by a physician and in accordance with relevant guidelines. Nevertheless, mixing vaccines may introduce uncertainties, such as potentially increasing the risk of adverse reactions or reducing immune effectiveness.

To ensure the safety and effectiveness of vaccination, individuals should prioritize receiving a booster vaccine that uses the same technology platform as their primary series. If mixed vaccination is necessary, it should be conducted under the guidance of a qualified healthcare professional, with close monitoring of post-vaccination reactions.

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