The Efficacy and Side Effects of Domperidone

In general, "Ma Ding Ning" refers to domperidone tablets. Its potential benefits may include promoting gastrointestinal motility, preventing and treating nausea and vomiting, improving symptoms of gastroesophageal reflux disease (GERD), relieving abdominal bloating and pain, and coordinating gastric and duodenal motility. Side effects may include gastrointestinal discomfort, allergic reactions, liver function impairment, nervous system damage, and endocrine system side effects. It is recommended to take the medication as directed by a physician. A detailed analysis is as follows:

I. Benefits

1. Promotes Gastrointestinal Motility
Domperidone tablets act directly on the gastrointestinal wall, effectively enhancing gastrointestinal motility and tone, thereby accelerating gastric emptying and helping relieve symptoms of indigestion and abdominal bloating.

2. Prevents and Treats Nausea and Vomiting
Since domperidone can cross the blood-brain barrier and block D2 receptors, it is effective in preventing and treating nausea and vomiting caused by surgery or chemotherapy.

3. Improves Symptoms of Gastroesophageal Reflux Disease
Domperidone tablets enhance the tone of the lower esophageal sphincter, reduce acid reflux, and effectively alleviate symptoms such as heartburn and acid regurgitation in patients with GERD.

4. Relieves Abdominal Bloating and Pain
For abdominal bloating and pain caused by indigestion, domperidone accelerates gastric emptying and reduces patient discomfort.

5. Coordinates Gastric and Duodenal Motility
Domperidone can also effectively coordinate the movement between the stomach and duodenum, contributing to improved gastrointestinal function.

II. Side Effects

1. Gastrointestinal Discomfort
After taking domperidone, some patients may experience adverse reactions such as nausea and vomiting, usually due to irritation of the gastric mucosa by the drug.

2. Allergic Reactions
A very small number of individuals may develop an allergic reaction to domperidone, manifesting as hives or shortness of breath.

3. Liver Function Impairment
Long-term excessive use of domperidone may adversely affect the liver, leading to abnormal liver function.

4. Nervous System Damage
Patients may experience headaches or dizziness after taking the drug, and in some cases, may develop restless legs syndrome or movement disorders.

5. Endocrine System Side Effects
Domperidone may affect serum prolactin levels, causing non-lactating women to produce breast milk and male patients to experience breast tenderness.

In daily life, it is important to maintain a balanced diet, exercise moderately, keep a regular sleep schedule, and avoid excessive fatigue to support overall physical and mental health.