How to Interpret C-Peptide Levels to Assess Pancreatic Beta-Cell Function
Nov 14, 2024
Source: Cainiu Health
Dr. Yang Shuwen
Introduction
Under normal circumstances, the assessment of pancreatic islet function mainly depends on the level of C-peptide. If the level is higher or lower than the normal range, it may indicate a problem with the function of pancreatic beta cells. C-peptide levels are mainly categorized into fasting C-peptide levels and postprandial (after-meal) C-peptide levels. It is generally recommended to maintain a healthy lifestyle, ensure balanced nutrition in the diet, control carbohydrate and fat intake, and consume more vegetables and high-quality protein.
Generally, assessing pancreatic islet function mainly depends on the level of C-peptide. If the level is higher or lower than the normal range, it may indicate a problem with the function of pancreatic beta cells. C-peptide levels mainly include fasting C-peptide and postprandial (after-meal) C-peptide levels.
The normal range for fasting C-peptide is generally 0.8–4.2 ng/mL. If the fasting C-peptide level is within the normal range, it suggests that the basal secretion function of the pancreatic beta cells is adequate. If the fasting C-peptide level is below the normal range, it may indicate a reduction in the number of pancreatic beta cells or impaired function. When the fasting C-peptide level exceeds the normal range, it may suggest that the body is compensating for blood glucose regulation by increasing insulin secretion from the pancreatic beta cells, thereby elevating C-peptide levels.
Postprandial C-peptide levels are higher than fasting levels. Under normal circumstances, C-peptide reaches its peak 1–2 hours after a meal, typically 5–10 times higher than fasting levels. If the postprandial C-peptide peak is delayed or does not reach at least 5 times the fasting level, this may indicate impaired pancreatic beta cell function.
It is recommended to maintain a healthy lifestyle, including balanced nutrition, controlled carbohydrate and fat intake, and increased consumption of vegetables and high-quality protein. Regular physical activity, such as brisk walking or swimming, can also help improve insulin sensitivity.
