What should not be eaten with high uric acid?

Generally, foods that are not suitable for individuals with high uric acid levels include high-purine animal offal, high-purine seafood, certain dried nuts, some vegetables and fruits, and high-fat foods. Medications that should be avoided include anti-tuberculosis drugs, diuretics, quinolone antibiotics, immunosuppressants, and other drugs. The detailed explanation is as follows:

I. Foods to Avoid

1. High-purine animal offal: Such as pork liver, chicken liver, and pig kidney. These foods generally contain high levels of purines, which can elevate uric acid levels.

2. High-purine seafood: Such as sardines, lobster, mackerel, and anchovies. These are all high-purine foods, and consumption by individuals with high uric acid can lead to excessive purine levels in the body, causing uric acid imbalance.

3. Some dried nuts: Such as peanuts, cashews, sunflower seeds, and pistachios. These foods contain moderate to high levels of purines and are not recommended for individuals with high uric acid.

4. Some vegetables and fruits: High-purine vegetables typically include soy sprouts, asparagus, shiitake mushrooms, and mushrooms. High-purine fruits usually include longan, papaya, grapes, and lemons. Although the purine content in these foods is relatively low, their intake should be moderated or restricted when uric acid levels are high.

5. High-fat foods: Such as chips, chocolate, hamburgers, and pizza. These foods not only contain high levels of fat but may also affect the excretion of uric acid. Patients with high uric acid should avoid consuming them.

II. Medications to Avoid

1. Anti-tuberculosis drugs: Such as isoniazid tablets and ethambutol hydrochloride tablets. These drugs significantly affect liver and kidney function, impairing the metabolism of uric acid in the liver and kidneys, leading to impaired uric acid excretion and elevated uric acid levels.

2. Diuretics: Such as compound furosemide tablets and valsartan hydrochlorothiazide capsules. Diuretics promote the reabsorption of uric acid by the renal tubules, thereby increasing the level of uric acid in the body and making it difficult to control uric acid levels.

3. Quinolone antibiotics: Such as ciprofloxacin hydrochloride tablets and moxifloxacin hydrochloride tablets. These medications can cause certain kidney damage after administration, leading to abnormal renal tubular secretion function and subsequently causing hyperuricemia.

4. Immunosuppressants: Such as cyclosporine capsules and tacrolimus capsules. These drugs increase the reabsorption of uric acid by the renal proximal tubules. Additionally, cyclosporine can cause damage to the circulatory system and renal tubules, impairing their normal function, reducing uric acid excretion, and leading to elevated uric acid levels.

5. Other medications: Such as low-dose aspirin with vitamin C enteric-coated tablets and levodopa tablets. Low-dose aspirin with vitamin C enteric-coated tablets inhibit the excretion of uric acid through the kidneys, leading to elevated serum uric acid levels. Levodopa tablets can be metabolized in the body into two substances: vanillic acid and homovanillic acid. These two substances compete with uric acid for excretion pathways in the kidneys, thereby hindering the normal excretion of uric acid and causing elevated serum uric acid levels.

Patients with high uric acid levels should also ensure adequate hydration, engage in appropriate aerobic exercise, and adjust their diet and medications under the guidance of a physician. If any discomfort occurs, timely medical consultation and professional treatment are necessary.