Why does brucellosis cause more pain at night?

Generally speaking, brucellosis refers to a zoonotic disease caused by Brucella species. Increased pain from brucellosis at night may be caused by factors such as vagus nerve excitation, impaired metabolism, muscle tension, intensified inflammatory response, and changes in nerve sensitivity. If discomfort symptoms occur, it is recommended to seek medical attention at a hospital promptly and follow standard treatment under a physician's guidance. Detailed explanations are as follows:

1. Vagus Nerve Excitation

The vagus nerve is more active at night than during the day, enhancing the transmission of pain signals by nerve endings and increasing the perception of pain at night, thus causing increased pain sensation. In daily life, gentle relaxation techniques such as deep breathing and meditation can be practiced to help alleviate pain.

2. Impaired Metabolism

At night, bodily activity decreases and internal circulation weakens, leading to impaired metabolism and accumulation of metabolic waste, which may intensify the sensation of pain. Engaging in mild physical activity at night, such as walking or yoga, can help promote blood circulation and metabolism. Maintaining good sleeping posture and avoiding pressure on painful areas is also recommended.

3. Muscle Tension

Patients with brucellosis may develop protective muscle tension due to prolonged pain. This tension may not be adequately relieved during nighttime rest and could even worsen, leading to increased pain. In daily life, engaging in mild physical activities such as yoga or tai chi may help relieve muscle tension.

4. Intensified Inflammatory Response

At night, immune system activity increases, intensifying the inflammatory response and resulting in more severe pain. Symptoms such as fever and fatigue may also occur. Under medical guidance, medications such as ibuprofen sustained-release tablets, indomethacin suppositories, and aspirin tablets may be used for treatment.

5. Changes in Nerve Sensitivity

Long-term inflammatory stimulation increases the sensitivity of peripheral nerves, resulting in hyperalgesia (increased sensitivity to pain). At night, with reduced distractions from daily activities, the pain may become more noticeable. Emotional fluctuations and anxiety may also occur. It is recommended to follow medical advice and use medications such as tramadol hydrochloride for injection, morphine hydrochloride tablets, and morphine sulfate sustained-release tablets for treatment.

In daily life, patients should maintain healthy lifestyle habits and a positive mindset, avoid excessive fatigue and emotional fluctuations, and apply heat or cold compresses to help alleviate pain.