Can glyburide effectively control blood sugar?

Under normal circumstances, common dosage forms of glibenclamide include tablets and capsules. Glibenclamide can effectively control blood glucose levels and should be used under the guidance of a physician. A detailed explanation is as follows:

Glibenclamide belongs to the sulfonylurea class of antidiabetic drugs. Its primary pharmacological action is to lower blood glucose by stimulating insulin release from pancreatic β-cells. Glibenclamide selectively binds to specific ATP-dependent sulfonylurea receptors on the membrane of pancreatic B cells, promoting accelerated glucose metabolism and thereby reducing plasma glucose levels. Additionally, it can inhibit glucagon secretion from pancreatic α-cells, further contributing to its hypoglycemic effect.

Glibenclamide is primarily used for blood glucose control in patients with type 2 diabetes, especially those with mild to moderate disease who still have some capacity for insulin synthesis and secretion by pancreatic β-cells. However, this medication should be contraindicated or used with caution in patients with type 1 diabetes, type 2 diabetes complicated by ketoacidosis or other stress conditions, hepatic or renal insufficiency, or a history of sulfonamide allergy.

During treatment with glibenclamide, patients need to closely monitor their blood glucose levels, as this medication carries a risk of hypoglycemia, particularly in elderly patients, those with impaired liver or kidney function, and those with concomitant medical conditions.