What medications are incompatible with Roxithromycin?
Jan 20, 2025
Source: Cainiu Health
Dr. Yang Ziqi
Introduction
The common dosage form of Roxithromycin is tablet. Under normal circumstances, Roxithromycin may interact with medications such as Moxifloxacin Hydrochloride Tablets, Metformin Hydrochloride Tablets, Cisapride Tablets, Terfenadine Tablets, and Warfarin Sodium Tablets. Therefore, when using Roxithromycin, it is important to carefully understand drug interactions and avoid concurrent use of incompatible medications.
Roxithromycin is commonly available in tablet form. Under normal circumstances, roxithromycin may interact with certain medications such as moxifloxacin hydrochloride tablets, metformin hydrochloride tablets, cisapride tablets, terfenadine tablets, and warfarin sodium tablets, potentially leading to adverse effects. Detailed explanations are as follows:
1. Moxifloxacin Hydrochloride Tablets: Moxifloxacin hydrochloride is a quinolone antibacterial drug that inhibits bacterial DNA replication and synthesis by suppressing the activity of bacterial DNA gyrase. Concurrent use of roxithromycin and moxifloxacin hydrochloride tablets may increase the risk of cardiac conduction abnormalities; therefore, these two medications should not be taken together.
2. Metformin Hydrochloride Tablets: Roxithromycin may slow down the metabolism of metformin hydrochloride, prolonging its retention time in the bloodstream. This may enhance the blood glucose-lowering effect of metformin hydrochloride and increase the risk of hypoglycemia.
3. Cisapride Tablets: Cisapride tablets are prokinetic agents that enhance lower esophageal sphincter tone and improve upper gastrointestinal motility disorders. Concurrent use of roxithromycin and cisapride may increase the risk of cardiac complications; therefore, these two medications should not be taken together.
4. Terfenadine Tablets: Terfenadine tablets are antihistamines primarily used to treat hypersensitivity reactions such as urticaria and pruritus. Concurrent administration with roxithromycin may similarly increase the risk of cardiac conduction abnormalities, so simultaneous use should be avoided.
5. Warfarin Sodium Tablets: Roxithromycin may inhibit the liver enzymes responsible for metabolizing warfarin sodium, thereby increasing its concentration in the bloodstream. This enhances the anticoagulant effect of warfarin sodium and increases the risk of bleeding.
When using roxithromycin, it is important to fully understand potential drug interactions and avoid concurrent use of incompatible medications. To prevent harm to the body, it is recommended that medication be taken under a physician's guidance.
