What are the side effects of Fluconazole?
Feb 14, 2025
Source: Cainiu Health
Dr. Bai Hongmei
Introduction
Under normal circumstances, fluconazole is commonly available in the following dosage forms: tablets, capsules, eye drops, and injections. The main side effects of fluconazole include gastrointestinal discomfort, abnormal liver function, skin allergic reactions, effects on the hematologic system, and nervous system reactions. When using fluconazole, it should be administered under the guidance of a physician, and bodily reactions should be closely monitored.
Under normal circumstances, fluconazole is commonly available in various dosage forms such as tablets, capsules, eye drops, and injections. The main side effects of fluconazole include gastrointestinal discomfort, skin allergic reactions, hepatotoxicity, neurological discomfort, and hematological system abnormalities. Detailed explanations are as follows:
1. Gastrointestinal Discomfort
After entering the gastrointestinal tract, fluconazole may directly irritate the gastrointestinal mucosa, affect normal gastrointestinal motility and digestive function, and interfere with acid-base balance and digestive enzyme activity in the gastrointestinal tract, thereby causing a series of gastrointestinal discomfort reactions. Symptoms may include nausea, vomiting, abdominal pain, and diarrhea.
2. Skin Allergic Reactions
Fluconazole may be recognized as an antigen by the human immune system, triggering an immune response. After antibodies produced by the immune system bind to the drug, immune cells are activated to release inflammatory mediators such as histamine, leading to skin vasodilation and increased permeability, which can result in allergic symptoms such as rash and itching.
3. Hepatotoxicity
Fluconazole is primarily metabolized through the liver, and during this process, it may cause damage to liver cells. The drug or its metabolites may interfere with normal metabolic processes within liver cells, leading to liver cell injury and subsequent abnormal liver function, such as elevated liver enzymes. In severe cases, jaundice may occur.
4. Neurological Discomfort
Fluconazole may enter the central nervous system by crossing the blood-brain barrier and exert certain effects on nerve cells, thus causing neurological discomfort symptoms such as dizziness and headache.
5. Hematological System Abnormalities
Fluconazole may exert a certain degree of inhibitory effect on bone marrow hematopoietic function, resulting in reduced blood cell production. Some patients may develop neutropenia and thrombocytopenia, and other changes in hematological parameters may also occur, such as anemia and somnolence.
When using fluconazole, it should be administered under the guidance of a physician, and physical responses should be closely monitored. If severe discomfort or abnormal symptoms occur, the physician should be informed promptly.
