Is there a risk of not undergoing amniocentesis with the third-generation IVF?
Apr 27, 2025
Source: Cainiu Health
Dr. Zhang Lu
Introduction
Under normal circumstances, there may be certain risks associated with not performing amniocentesis during the third-generation IVF (in vitro fertilization) procedure. Although during the third-generation IVF process, embryos undergo chromosomal and genetic-level testing prior to implantation, which allows for the selection of embryos carrying genetic diseases or chromosomal abnormalities, thereby reducing the likelihood of the fetus developing severe genetic disorders.
Generally speaking, the term "third-generation IVF" refers to the third-generation in vitro fertilization technology, while amniocentesis refers to the medical procedure of amniotic fluid puncture. Not performing amniocentesis after third-generation IVF may carry certain risks. The specific analysis is as follows:
During third-generation IVF, although embryos are tested for chromosomal and genetic abnormalities prior to implantation, thereby enabling the selection of embryos carrying genetic diseases or chromosomal abnormalities and reducing the likelihood of the baby developing severe genetic disorders, preimplantation genetic testing is not infallible and has certain limitations. For example, the testing does not cover all possible gene and chromosomal abnormalities.
Amniocentesis, on the other hand, is a prenatal diagnostic method performed during pregnancy that allows direct acquisition of fetal cells for chromosomal and genetic analysis, providing more comprehensive and accurate results. If amniocentesis is not performed after third-generation IVF, there is a possibility of missing certain chromosomal microdeletions, microduplications, or other de novo genetic mutations that were not detected before embryo implantation, which may lead to fetal developmental abnormalities, intellectual disabilities, and other serious consequences.
In daily life, maintaining healthy pregnancy habits, such as balanced nutrition, moderate exercise, and avoiding exposure to harmful substances, can help reduce the risk of fetal abnormalities.
