How long does it take for ABO hemolytic jaundice to resolve completely?
Jul 09, 2025
Source: Cainiu Health
Dr. Shen Yonghua
Introduction
ABO hemolytic jaundice generally resolves within 1 to 4 weeks. If hemolysis is severe, excessive bilirubin production occurs, or the newborn is premature or has infections, the liver's ability to metabolize bilirubin may be compromised, leading to prolonged jaundice resolution, which may take 2 to 4 weeks. In such cases, continuous phototherapy or even exchange transfusion may be required, as bilirubin levels decline slowly and the jaundice resolution process is prolonged.
Generally, ABO hemolytic jaundice usually resolves within 1 to 4 weeks. If there are any concerns, it is recommended to seek medical advice in advance. Detailed analysis is as follows:
When the hemolysis is severe, excessive bilirubin is produced, or the newborn is premature or has infections, the liver's ability to metabolize bilirubin may be limited. As a result, the jaundice may take longer to resolve, possibly requiring 2 to 4 weeks. In such cases, continuous phototherapy or even exchange transfusion may be needed, and bilirubin levels decline slowly, prolonging the resolution of jaundice.
If the hemolysis is mild, bilirubin levels do not rise significantly, and the newborn's liver function is good without other complications, timely interventions such as phototherapy can rapidly promote bilirubin metabolism and excretion. In such cases, jaundice typically resolves within 1 to 2 weeks.
Close monitoring of bilirubin levels is essential for ABO hemolytic jaundice. Measures such as phototherapy should be taken as advised by a physician to prevent bilirubin-induced neurological damage and ensure the newborn's health.
