What causes uneven endometrial echogenicity?

Jul 19, 2025 Source: Cainiu Health
Dr. Zhang Lu
Introduction
In general, uneven endometrial echogenicity may be caused by factors such as the endometrial repair phase after menstruation, endometrial hyperemia during ovulation, endometritis, endometrial polyps, or submucosal uterine fibroids. It is recommended to seek timely medical attention to determine the exact cause and receive appropriate treatment under a doctor's guidance. In daily life, it is important to maintain menstrual hygiene, avoid sexual intercourse during menstruation, and reduce the risk of intrauterine infection.

Generally, uneven endometrial echoes may be caused by factors such as the endometrial repair phase after menstruation, endometrial hyperemia during ovulation, endometritis, endometrial polyps, or submucosal uterine fibroids. It is recommended to seek timely medical consultation to identify the underlying cause and receive appropriate treatment under a doctor's guidance. Detailed analysis is as follows:

1. Endometrial repair phase after menstruation: After menstruation ends, incomplete shedding of the endometrium and uneven thickness of local tissue during the repair process may lead to uneven echoes. This is a normal physiological phenomenon that requires no special treatment. Observation of subsequent menstrual cycles is sufficient.

2. Endometrial hyperemia during ovulation: Elevated estrogen levels during ovulation can cause endometrial hyperemia and edema, potentially leading to uneven echoes. This typically resolves spontaneously with the menstrual cycle. Maintaining external genital hygiene and avoiding excessive fatigue are recommended.

3. Endometritis: Pathogen infection引发 inflammation of the endometrium, with inflammatory stimulation causing edema and uneven proliferation of endometrial tissue, often accompanied by lower abdominal pain and increased vaginal discharge. Patients may follow medical advice to use medications such as cefuroxime axetil tablets, metronidazole tablets, or Jin Gangteng capsules to control the infection.

4. Endometrial polyps: Localized excessive endometrial proliferation forms polyps, leading to uneven endometrial structure, possibly accompanied by prolonged menstrual periods or increased menstrual flow. Smaller polyps may be treated with medications such as progesterone soft capsules, dydrogesterone tablets, or medroxyprogesterone acetate tablets as directed by a physician to promote polyp shedding. Larger polyps require hysteroscopic polypectomy to remove the abnormally proliferative tissue and restore normal endometrial structure.

5. Submucosal uterine fibroids: Fibroids growing into the uterine cavity protrude from the endometrial surface, causing uneven echoes, possibly accompanied by increased menstrual flow or prolonged menstrual periods. Small fibroids can be treated with medications such as leuprolide acetate microspheres for injection, mifepristone tablets, or Guizhi Fuling capsules as directed by a physician to reduce fibroid size. Larger fibroids require hysteroscopic myomectomy to remove the fibroids and improve the endometrial environment.

In daily life, attention should be paid to menstrual hygiene, avoiding sexual intercourse during menstruation to reduce the risk of intrauterine infection. Maintaining a regular sleep schedule, avoiding late nights, eating a balanced diet, and reducing intake of high-fat and high-sugar foods are also recommended. Regular gynecological examinations should be conducted to promptly detect and manage abnormalities.

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