Is uric acid level related to kidney function?

Jul 28, 2025 Source: Cainiu Health

Dr. Yang Tiesheng

Introduction

The kidneys are the primary organs responsible for uric acid excretion. When kidney function declines, the ability to excrete uric acid weakens, potentially leading to elevated uric acid levels. In such cases, changes in both kidney function and uric acid levels often occur together, and both kidney function indicators and uric acid levels should be monitored during examinations. If increased uric acid levels are caused by excessive intake of purines from diet or metabolic disorders, while kidney function tests remain normal.

Generally, uric acid levels are associated with kidney function to some extent. Abnormal kidney function may affect the excretion of uric acid. However, elevated uric acid levels are not always caused by kidney dysfunction. A detailed explanation is as follows:

The kidneys are the primary organs responsible for uric acid excretion. When kidney function declines, the ability to excrete uric acid may weaken, potentially leading to elevated uric acid levels. In such cases, changes in both kidney function and uric acid levels often occur together. Therefore, both kidney function indicators and uric acid levels should be monitored during examinations.

If elevated uric acid levels result from excessive intake of purine-rich foods or metabolic disorders while kidney function tests are normal, changes in uric acid levels are not directly related to kidney function. In such cases, uric acid levels may return to the normal range through dietary adjustments, increased physical activity, and other lifestyle modifications.

Abnormal uric acid or kidney function indicators should be evaluated comprehensively with multiple tests. If symptoms such as joint pain or edema occur, timely medical consultation is necessary to identify the underlying cause. Interventions should follow professional recommendations to avoid overlooking abnormalities in individual indicators.

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