At what age does neurofibromatosis occur?
Aug 26, 2025
Source: Cainiu Health
Dr. Wang Lei
Introduction
In general, the age of onset for neurofibromatosis is not fixed and mainly depends on the disease type. Neurofibromatosis type 1 often manifests in childhood, while neurofibromatosis type 2 commonly occurs during adolescence to early adulthood. To better manage the condition, families with a history of the disease are advised to schedule regular physical examinations for their children or adolescents.
Generally, the age of onset for neurofibromatosis is not fixed and mainly depends on the disease type. Neurofibromatosis type 1 often manifests during childhood, while neurofibromatosis type 2 commonly occurs between adolescence and young adulthood. A detailed analysis is as follows:
Neurofibromatosis type 1 is the more common form. Most patients begin to show symptoms around age 5, such as café-au-lait spots on the skin. With aging, skin or subcutaneous neurofibromas may gradually appear. After onset in childhood, symptoms slowly become evident with growth and development, and some patients may experience more noticeable symptoms during puberty.
Neurofibromatosis type 2 is relatively rare, with a later onset age compared to neurofibromatosis type 1. Most patients begin to exhibit symptoms between ages 15 and 25, during adolescence to young adulthood. Common symptoms include hearing loss and tinnitus. As the disease progresses, neurofibromas may gradually develop.
To better manage the condition, families with a history of the disease are advised to schedule regular physical examinations for children or adolescents to detect symptoms early. In daily life, maintaining a regular routine and avoiding excessive fatigue is recommended.
