At what age do neurofibromas typically develop?
Aug 26, 2025
Source: Cainiu Health
Dr. Wang Lei
Introduction
In general, the age at which tumors develop in neurofibromatosis is not fixed and mainly depends on the disease type. Individuals with Neurofibromatosis type 1 (NF1) often develop tumors from childhood to adolescence, while those with Neurofibromatosis type 2 (NF2) commonly develop tumors during adolescence to early adulthood. To better manage the condition, it is recommended to undergo regular physical examinations, especially for individuals with a family history of the disease, who should begin monitoring at an earlier age.
Generally, the age at which neurofibromas appear is not fixed and mainly depends on the type of disease. Neurofibromatosis type 1 usually develops tumors from childhood to adolescence, while neurofibromatosis type 2 commonly develops tumors from adolescence to young adulthood. Detailed analysis is as follows:
Neurofibromatosis type 1 is the more common type. Most patients begin to develop skin pigmentation spots around age 5. As they age, neurofibromas gradually develop on or under the skin surface during childhood to adolescence. Initially, these tumors may be small in size and limited in number, but they may gradually increase in number and grow larger as the patient develops.
Neurofibromatosis type 2 is relatively rare, with tumors often originating from the auditory nerve, vestibular nerve, and others. Patients typically begin to experience symptoms during adolescence. As the condition progresses, tumors gradually develop during young adulthood, possibly accompanied by hearing loss, tinnitus, and other manifestations.
To better manage the condition, it is recommended to undergo regular physical examinations, especially for individuals with a family history of the disease who should start monitoring at an earlier age. Maintaining skin cleanliness in daily life and choosing loose, soft clothing can help reduce irritation to areas where tumors may develop.
