What is the difference between Loxoprofen Sodium Tablets and Ibuprofen?

Common dosage forms of ibuprofen include tablets and capsules. Under normal circumstances, the differences between loxoprofen sodium tablets and ibuprofen are reflected in aspects such as intensity of action, onset time, types of inflammation applicable, degree of gastrointestinal irritation, and usage restrictions for special populations. Detailed analysis is as follows:

1. Intensity of Action

Loxoprofen sodium tablets belong to prodrugs, which are converted into active forms in the body to exert effects. Their anti-inflammatory and analgesic effects are generally stronger than those of ibuprofen, making them more effective for relieving severe joint inflammation and postoperative pain. Ibuprofen's anti-inflammatory and analgesic effects are relatively milder, making it more suitable for relieving mild to moderate pain and common inflammation.

2. Onset Time

Due to the drug conversion process, loxoprofen sodium tablets have a slightly slower onset, typically starting to take effect about 1-2 hours after administration. Ibuprofen does not require conversion and acts relatively faster, generally showing effects within 0.5-1 hours after taking the medication, making it suitable for situations requiring rapid pain or fever relief.

3. Types of Inflammation Applicable

Loxoprofen sodium tablets are more widely used in the treatment of chronic joint inflammations such as rheumatoid arthritis and osteoarthritis, effectively controlling symptoms like joint swelling and pain. Besides relieving common inflammation, ibuprofen is more frequently used for alleviating acute symptoms such as common cold fever, acute headaches, and dysmenorrhea.

4. Degree of Gastrointestinal Irritation

Both medications may cause gastrointestinal discomfort, but loxoprofen sodium tablets have relatively less direct irritation to the gastrointestinal mucosa because their prodrug form has low activity in the gastrointestinal tract. Ibuprofen causes relatively more noticeable gastrointestinal irritation and may easily induce nausea, stomach pain, and other discomforts when taken on an empty stomach, so attention should be paid to the timing of administration.

5. Usage Restrictions for Special Populations

Loxoprofen sodium tablets are not recommended for individuals with severe liver or kidney dysfunction or severe heart failure. In addition to the above restrictions, ibuprofen should be used cautiously in patients with hyperthyroidism, as it may increase metabolic burden on the body, and consultation with a physician is necessary before use.

Additionally, neither drug should be taken in excessive amounts for prolonged periods to avoid liver and kidney function damage. Both are contraindicated in individuals allergic to nonsteroidal anti-inflammatory drugs (NSAIDs). If allergic reactions such as rashes or difficulty breathing occur during medication use, discontinue use immediately and seek medical attention.