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Which is safer, ibuprofen or acetaminophen?

Sep 11, 2025 Source: Cainiu Health
Dr. Yang Ziqi
Introduction
The common dosage forms of ibuprofen and acetaminophen are tablets. Generally speaking, it is not appropriate to claim that one is safer than the other between ibuprofen and acetaminophen, as they are indicated for different conditions, and therefore their safety profiles cannot be directly compared. When using either medication, it is important to strictly follow the recommended dosage and dosing intervals. Neither medication should be taken in excessive amounts or for prolonged periods.

　　The common dosage forms of ibuprofen and acetaminophen are tablets. Generally speaking, there is no definitive answer to the question of "which is safer between ibuprofen and acetaminophen," as they are indicated for different conditions, and therefore their safety profiles cannot be directly compared. Detailed analysis is as follows:

　　Acetaminophen has a relatively high safety profile when used within the recommended dosage and is suitable for individuals aged two months and older. It has minimal gastrointestinal irritation and rarely causes gastrointestinal discomfort. Under normal usage, it has little impact on liver and kidney function, and only in cases of overdose may it lead to liver damage. It is suitable for individuals with sensitive gastrointestinal systems and normal liver and kidney function, especially for young infants and children.

　　Ibuprofen is suitable for individuals aged six months and older and has good safety profile when used at the recommended dosage. However, it may cause some gastrointestinal irritation, and some individuals may experience symptoms such as stomach pain and nausea after use. Long-term or overdose use may affect kidney function. However, the risk is low when used at the recommended dosage for a short period. It is suitable for individuals without gastrointestinal diseases and with normal kidney function, and is used to relieve fever and symptoms related to inflammation.

　　When using these medications, it is important to strictly follow the recommended dosage and dosing intervals, and avoid overdose or long-term use. Patients with gastrointestinal diseases should prioritize acetaminophen, while those with underlying kidney disease should consult a physician before using ibuprofen. Monitor for any adverse reactions during medication use; if symptoms such as rash or vomiting occur, discontinue the medication immediately and seek medical attention. Avoid taking combination medications containing the same ingredients simultaneously to prevent duplicated drug intake.

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