What are the side effects of the 9-valent human papillomavirus vaccine?
Sep 16, 2025
Source: Cainiu Health
Dr. Zhang Lu
Introduction
In general, possible side effects after receiving the 9-valent human papillomavirus (HPV) vaccine mainly include local reactions at the injection site, mild fever, fatigue, headache, muscle and joint pain, and skin allergic reactions. Most side effects are mild in severity and short in duration. After receiving the 9-valent HPV vaccine, individuals should remain at the vaccination site for 30 minutes of observation and may leave only if no abnormal reactions occur.
Generally, after receiving the 9-valent human papillomavirus (HPV) vaccine, possible side effects mainly include local reactions at the injection site, mild fever, fatigue and headache, muscle and joint pain, and skin allergic reactions. Most side effects are mild in severity and short in duration. A detailed analysis is as follows:
1. Local reactions at the injection site: This is the most common side effect, manifesting as redness, pain, and hard lumps at the injection site. Some individuals may experience slight itching or rash. Symptoms usually appear several hours to 1-2 days after vaccination and generally require no special treatment.
2. Mild fever: A small number of vaccinated individuals may develop a low-grade fever, with body temperature generally between 37.3-38°C. Fever typically appears within one day after vaccination and resolves spontaneously within 1-2 days. Drinking more warm water and resting can help alleviate symptoms.
3. Fatigue and headache: Some individuals may feel fatigued or experience mild headache after vaccination, often described as a dull ache that does not interfere with normal daily activities. This discomfort usually gradually subsides within 1-2 days after vaccination, and adequate rest can help relieve symptoms.
4. Muscle and joint pain: A small number of vaccinated individuals may experience muscle pain in the arm on the injection side or mild joint pain in other parts of the body. This discomfort is usually temporary. The pain is generally mild, and avoiding strenuous physical activity will allow symptoms to resolve on their own.
5. Skin allergic reactions: Very rarely, individuals with allergic constitutions may develop allergic symptoms such as widespread rashes, itching, or localized skin swelling and redness. If allergic reactions occur, it is important to promptly inform the vaccination staff.
After receiving the 9-valent HPV vaccine, individuals should remain at the vaccination site for 30 minutes of observation and leave only if there are no abnormal reactions. For 1-2 days after vaccination, avoid getting the injection site wet, maintain a light diet, avoid strenuous exercise, and ensure regular sleep patterns to help the body better adapt to the vaccine response.
