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What is the best medication for lowering cholesterol?

Sep 16, 2025 Source: Cainiu Health
Dr. Gao Jun
Introduction
Generally speaking, there is no such thing as "the best medication for lowering cholesterol." Elevated cholesterol is associated with abnormal lipid metabolism, and prolonged high levels may increase the risk of cardiovascular diseases. Patients can take medications such as atorvastatin calcium tablets, rosuvastatin calcium tablets, ezetimibe tablets, fenofibrate capsules, and probucol tablets under medical guidance.

Generally speaking, there is no such thing as a "best medication for lowering cholesterol." Elevated cholesterol is associated with abnormal lipid metabolism, and prolonged high levels may increase the risk of cardiovascular diseases. Patients can follow medical advice to use medications such as atorvastatin calcium tablets, rosuvastatin calcium tablets, ezetimibe tablets, fenofibrate capsules, and probucol tablets for treatment. Detailed analysis is as follows:

1. Atorvastatin Calcium Tablets

Atorvastatin calcium belongs to the statin class of drugs. It reduces cholesterol production by inhibiting a key enzyme involved in cholesterol synthesis in the liver, while also mildly increasing high-density lipoprotein (HDL) cholesterol levels. It is commonly used to treat hypercholesterolemia and mixed hyperlipidemia.

2. Rosuvastatin Calcium Tablets

This is also a statin drug with a mechanism of action similar to atorvastatin calcium. It effectively lowers total cholesterol and low-density lipoprotein (LDL) cholesterol, exerting a strong inhibitory effect on cholesterol synthesis in the liver. It is suitable for patients who require further lipid regulation despite dietary control.

3. Ezetimibe Tablets

Ezetimibe works by inhibiting the absorption of cholesterol in the small intestine, including dietary cholesterol and cholesterol from bile, thereby reducing the amount of cholesterol entering the bloodstream. It can be used alone or in combination with statins to enhance cholesterol-lowering effects.

4. Fenofibrate Capsules

Fenofibrate capsules belong to the fibrate class of drugs. They primarily activate peroxisome proliferator-activated receptors to promote triglyceride breakdown, while also lowering total cholesterol and LDL cholesterol and raising HDL cholesterol. They are suitable for patients with hypertriglyceridemia or mixed hyperlipidemia predominantly characterized by elevated triglycerides.

5. Probucol Tablets

Probucol lowers total cholesterol and LDL cholesterol by inhibiting cholesterol absorption and synthesis in the intestine. Additionally, it has antioxidant properties that help protect vascular endothelial cells. It is indicated for hypercholesterolemia and is particularly suitable for patients with homozygous familial hypercholesterolemia.

Maintaining healthy lifestyle habits in daily life—such as reducing intake of high-cholesterol and high-fat foods (e.g., animal offal, fried foods), and engaging in appropriate physical activity—can help control cholesterol levels.

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