What are the contraindications of ferrous fumarate granules?

Under normal circumstances, contraindications for ferrous fumarate granules include: patients with non-iron-deficiency anemia, those with severe liver or kidney dysfunction, individuals allergic to iron preparations or excipients in the medication, patients with acute infections, and those with active peptic ulcers. Specific analysis is as follows:

1. Contraindicated in patients with non-iron-deficiency anemia: Conditions such as hemolytic anemia or megaloblastic anemia do not involve reduced iron stores. Taking ferrous fumarate granules may lead to excessive iron accumulation, causing iron deposition in vital organs like the liver and heart, resulting in iron toxicity and worsening organ damage.

2. Contraindicated in patients with severe hepatic or renal insufficiency: The liver plays a central role in iron storage and metabolism. In cases of severe liver dysfunction, iron metabolism is impaired, making iron accumulation more likely after iron supplementation. Patients with kidney dysfunction have reduced excretory capacity, which may increase the metabolic burden on the kidneys. Additionally, anemia associated with renal insufficiency typically requires targeted treatment with erythropoietin-stimulating agents rather than simple iron supplementation. Indiscriminate use of iron increases the risk of adverse reactions.

3. Contraindicated in individuals allergic to iron preparations or drug excipients: Patients with hypersensitivity to ferrous fumarate or any of the inactive ingredients (such as fillers or binders) may develop allergic reactions including rash and itching after ingestion. Severe cases could progress to anaphylactic shock, which can be life-threatening. Therefore, these individuals must strictly avoid this medication and switch to alternative anti-anemia treatments.

4. Contraindicated during acute infection: During acute infection, the body is under inflammatory stress. Iron supplementation at this stage may promote the growth of bacteria or viruses, exacerbating the infection. Moreover, infection can impair iron absorption and utilization, reducing the effectiveness of the drug. Iron supplementation should only be considered after the infection has been controlled.

5. Contraindicated in patients with active peptic ulcer disease: Ferrous fumarate granules are irritating to the gastrointestinal mucosa and may cause nausea, vomiting, and stomach pain. In patients with active peptic ulcers, the gastric mucosa is already damaged; taking this medication may worsen mucosal injury and potentially trigger ulcer bleeding or perforation. Use should be delayed until ulcer healing, and even then, only under careful medical supervision.

To ensure safety, consult a physician or pharmacist before using any medication—especially for long-term or high-dose therapy. Always follow medical advice and instructions carefully to avoid risks associated with self-medication. Additionally, monitor your body's response after taking the medication, and seek prompt medical attention if any adverse effects occur.