Is choroid plexus cyst related to autism?

Nov 20, 2025 Source: Cainiu Health

Dr. Zhou Xiaofeng

Introduction

Simple physiological choroid plexus cysts are not directly associated with autism. If the choroid plexus cyst is physiological, it usually appears during the fetal or infant stage and often resolves spontaneously as the child grows and develops. It does not affect brain structure or function, and when there are no other chromosomal abnormalities or developmental issues, such cases show no significant link to the development of autism, so excessive concern is unnecessary.

Generally, isolated physiological choroid plexus cysts are not directly associated with autism. However, if the cyst persists or is accompanied by other abnormalities, caution is warranted. If concerned, it is recommended to seek medical advice early. Detailed analysis is as follows:

If the choroid plexus cyst is physiological, it usually appears during the fetal or infant stage and often resolves spontaneously with growth and development. When it does not affect brain structure or function and there are no other chromosomal abnormalities or developmental issues, there is no significant association with autism, and excessive concern is unnecessary.

If the choroid plexus cyst is pathological—persisting long-term without spontaneous absorption—or is accompanied by brain structural abnormalities, chromosomal abnormalities (such as trisomy 21), or developmental delays, it may indirectly increase the risk of neurodevelopmental disorders. Since autism falls within the spectrum of neurodevelopmental disorders, further evaluation is needed in such cases to assess potential associations.

After detection of a choroid plexus cyst, regular follow-up examinations should be conducted as advised by a physician to monitor changes in the cyst. If symptoms such as delayed language development or impaired social interaction emerge, timely professional assessment is essential to avoid delaying intervention and to support normal psychological and physical development.

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