Can sacubitril be taken with sertraline?

Generally, it is acceptable to take these medications together if a doctor evaluates the condition as necessary and finds no contraindications. However, it is not recommended if there is a risk of drug interactions or individual intolerance. If in doubt, it is advisable to consult a healthcare professional in advance. Detailed analysis is as follows:

Sacubitril is commonly used in combination with valsartan to treat heart failure, while sertraline is used for depression or anxiety-related disorders. If a patient suffers from both heart failure and a psychiatric condition, and after evaluation shows no severe liver or kidney dysfunction, has no history of allergy to either medication, and the benefits of combined use are deemed to outweigh the risks, a physician may adjust the dosages of both drugs accordingly. In such cases, the medications can be taken together as prescribed, with close monitoring of physiological indicators.

However, in patients with severe renal impairment, combining sacubitril and sertraline may increase the metabolic burden on the kidneys. Additionally, since both drugs may affect electrolyte balance, their combined use could elevate the risk of electrolyte disturbances. Self-administering these medications without medical evaluation may lead to drug interactions that reduce efficacy or cause adverse effects such as dizziness or hypotension. In these situations, concurrent use should be avoided, and a safer treatment plan should be determined under medical supervision.

During treatment with sacubitril and sertraline, patients must strictly adhere to the prescribed dosages, avoid adjusting or discontinuing medication without guidance, undergo regular follow-up tests for liver and kidney function and electrolyte levels, and promptly report any physical discomfort to their doctor to ensure both safety and therapeutic effectiveness.