Which is easier to discontinue, sertraline or amitriptyline?

Sertraline is relatively easier to discontinue compared to amitriptyline. Sertraline has a milder mechanism of action, resulting in a lower incidence and milder symptoms of withdrawal reactions. In contrast, amitriptyline contains two active components, and abrupt discontinuation often leads to noticeable discomfort, requiring a slower tapering process. If severe mood fluctuations or physical discomfort occur during discontinuation, prompt medical attention is recommended.

Sertraline is a selective serotonin reuptake inhibitor (SSRI) with a single pharmacological target, allowing the body to adapt better during long-term use. When discontinuing sertraline, gradually reducing the dose helps minimize abrupt fluctuations in neurotransmitter levels. Most individuals experience only mild symptoms such as dizziness or fatigue, which are typically short-lived.

Amitriptyline is a combination preparation containing flupenthixol and amitriptyline, providing both antipsychotic and antidepressant effects. Due to its complex composition and broad mechanism of action, sudden discontinuation may trigger withdrawal symptoms such as insomnia, anxiety, and palpitations. Some individuals may also experience rebound emotional disturbances, necessitating a longer discontinuation period.

Discontinuation should always be conducted gradually under medical supervision—abrupt cessation must be avoided. During this period, maintain regular sleep patterns and avoid stressors; communicate regularly with family and friends to maintain emotional stability; follow a light, balanced diet and engage in moderate exercise to support the body’s smooth transition.