Does venlafaxine increase or decrease estrogen?

Under normal circumstances, venlafaxine neither increases nor decreases estrogen levels. If any abnormal symptoms occur, it is recommended to seek medical attention promptly. The detailed analysis is as follows:

Venlafaxine is an antidepressant that primarily acts on the reuptake processes of norepinephrine and serotonin, improving symptoms of depression and anxiety by modulating these two neurotransmitters. Its mechanism of action is not directly related to hormone regulation, and therefore does not significantly affect estrogen levels. Most clinical studies and patient reports indicate that estrogen levels do not exhibit consistent fluctuations after taking venlafaxine.

Some patients may experience menstrual irregularities or decreased libido after starting the medication; however, these effects are not directly caused by changes in estrogen levels, but rather result from the indirect influence of antidepressants on the hypothalamic-pituitary-gonadal axis. Such symptoms are usually associated with individual sensitivity, dosage, or concomitant medications, and can often be alleviated by adjusting the treatment plan.

During treatment, hormone levels and bodily responses should be monitored regularly. If persistent menstrual abnormalities or worsening mood swings occur, patients should promptly contact their doctor to evaluate whether dosage adjustment or a change in treatment strategy is needed.