Can paroxetine be replaced with lorazepam?

Generally, whether paroxetine can be switched to lorazepam should be evaluated by a doctor. A switch may be considered if it aligns with the treatment needs and there are no contraindications; otherwise, it is not recommended. If in doubt, it is advised to consult a healthcare provider in advance. Detailed analysis is as follows:

If a patient was originally taking paroxetine to manage anxiety symptoms but experienced inadequate efficacy or significant side effects, and the doctor determines that lorazepam is more suitable for short-term relief of anxiety—such as managing acute anxiety episodes—a switch may be made gradually under medical guidance, with close monitoring of physical responses.

However, if paroxetine is being used to treat depression or for long-term control of anxiety symptoms, switching directly to lorazepam is generally not recommended. This is because lorazepam works differently (primarily suited for short-term anxiety) and carries a risk of dependence with prolonged use, which could interfere with depression treatment or increase dependency risks.

Prior to changing medications, patients should inform their doctor about their medication history, effectiveness, and any side effects. Medications should never be discontinued or changed without medical supervision; dosage adjustments must follow a physician's instructions. During the transition period, monitor emotional and physical changes closely, and seek prompt medical advice if any adverse reactions occur.