Can lorazepam and fluoxetine be used together?
Nov 24, 2025
Source: Cainiu Health
Dr. Zhang Baohua
Introduction
In general, lorazepam and fluoxetine should not be used simultaneously. Adequate sleep must be ensured during treatment, and staying up late should be avoided to prevent disruption of neurological regulation rhythms. Maintain a light and balanced diet, avoid spicy and irritating foods, and reduce the body's metabolic burden. Monitor mental status and physical responses closely; if abnormal drowsiness, weakness in limbs, or other unusual symptoms occur, seek medical attention promptly.
Generally, lorazepam and fluoxetine should not be used simultaneously. The detailed analysis is as follows:
Both lorazepam and fluoxetine act on the central nervous system, and their combined use enhances central inhibitory effects. Lorazepam belongs to the benzodiazepine class of drugs and works by suppressing neural excitation transmission, while fluoxetine is a selective serotonin reuptake inhibitor that functions by regulating neurotransmitters. When used together, these medications may exacerbate symptoms such as drowsiness and dizziness, increase the risk of cognitive decline and impaired coordination, interfere with daily activities like walking or operating machinery, and potentially lead to serious adverse reactions such as respiratory depression, imposing multiple burdens on the body.
During treatment, ensure adequate sleep and avoid staying up late to prevent disruption of neurological regulation rhythms. Maintain a light, balanced diet, avoid spicy and irritating foods, and reduce metabolic burden on the body. Closely monitor mental status and physical responses; if excessive drowsiness, weakness, or other abnormalities occur, seek medical attention promptly. When going out, have someone accompany you, and avoid engaging in high-risk activities such as driving or working at heights alone, to ensure safety and stability during medication use.
