Are there any side effects of benzocaine?

Nov 24, 2025 Source: Cainiu Health
Dr. Wang Lei
Introduction
When benzocaine is used correctly for a short period, such as topical application to relieve minor pain on small areas of skin or mucous membranes, mild side effects like slight stinging, itching, or redness may occur. These discomforts are usually brief and gradually disappear after discontinuing the medication; in such cases, there is no need for excessive concern. However, if benzocaine is used in excessive doses or for prolonged periods, serious side effects may be triggered.

Under normal circumstances, benzocaine may cause mild local discomfort that usually resolves on its own, but rare yet serious adverse reactions are possible and should be taken seriously. If in doubt, it is advisable to consult a healthcare provider in advance. Detailed analysis is as follows:

When used correctly for short periods—such as topical application to relieve minor pain on small areas of skin or mucous membranes—benzocaine may cause mild stinging, itching, or redness. These symptoms are typically brief and gradually disappear after discontinuing the medication, so there is generally no need for excessive concern.

However, if benzocaine is used in excessive doses, for prolonged durations, or by individuals who are sensitive to the ingredient, severe side effects may occur. These include blistering or swelling of the skin, and even methemoglobinemia, which manifests as bluish discoloration of the lips, difficulty breathing, and other symptoms. In such cases, discontinue use immediately and seek emergency medical attention.

Before using benzocaine, ensure there is no history of related allergy. Strictly follow the instructions on the label or your doctor's advice regarding dosage and duration. Monitor your body's response during use, and discontinue the product and consult a healthcare professional promptly if any unusual discomfort occurs.

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