What are the side effects of xylometazoline hydrochloride nasal spray?
Nov 26, 2025
Source: Cainiu Health
Dr. Lu Cheng
Introduction
Common side effects of oxymetazoline hydrochloride nasal spray include local nasal irritation, drug-induced rhinitis, headache, dizziness, increased heart rate, and allergic reactions. After using the medication, users may experience dryness, a burning sensation, or mild pricking pain in the nasal cavity. Some individuals may also have a temporary worsening of nasal congestion, mostly due to direct irritation of the nasal mucosa by the drug, which is usually more noticeable during the initial period of treatment.
Common side effects of xylometazoline hydrochloride nasal spray include local nasal irritation, drug-induced rhinitis, headache and dizziness, increased heart rate, and allergic reactions. Detailed analysis is as follows:
1. Local nasal irritation: After use, dryness, burning sensation, or mild pricking pain in the nasal cavity may occur. Some users may also experience temporary worsening of nasal congestion, mostly due to direct irritation of the nasal mucosa by the medication. These symptoms are usually more noticeable during the initial period of use.
2. Drug-induced rhinitis: Prolonged continuous use (more than 7 days) can easily lead to this side effect, characterized by recurrent and progressively worsening nasal congestion. Symptoms become more pronounced after discontinuation, creating a dependency on the medication for relief. In severe cases, it may cause nasal mucosal hyperplasia and impair normal nasal function.
3. Headache and dizziness: A small number of users may experience a sensation of head fullness or mild vertigo, often related to the drug's vasoconstrictive properties and indirect effects on the nervous system. These symptoms are generally mild and gradually resolve after stopping the medication.
4. Increased heart rate: Some individuals may experience a faster heartbeat or occasional palpitations after using the spray. This occurs because the drug may be absorbed through the nasal mucosa and affect the cardiovascular system. Individuals with a history of cardiovascular disease should exercise particular caution.
5. Allergic reactions: Although rare, they can occur and manifest as nasal mucosal swelling, itching, skin rash, or facial flushing. If such symptoms appear, discontinue use immediately to prevent worsening of the allergic reaction.
When using this nasal spray, strictly follow the instructions in the product leaflet or medical advice regarding duration and dosage. Do not use continuously for more than 7 days. If severe side effects occur or symptoms persist without improvement, seek medical attention promptly to adjust the treatment plan.
